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KMID : 0378019740170091203
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New Medical Journal
1974 Volume.17 No. 9 p.1203 ~ p.1207
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Effects of Reduced Glutathione and Ginseng Extract on Protein Content of the Mouse Liver Following Whole Body X-Irradiation
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蔡洙喜/Chae, Soo Hi
權得基/金容彦/崔聖邱/Kwon, Duck Kee/Kim, Yang Eon/Choi, Sung Ku
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Abstract
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In an attempt to clarify the radioprotective effect of reduced glutathione (GSH), and to observe a possible radioprotective effect of Ginseng extract, whole body X-irradiation of 1, 200R was administered to the mouse either independently or immediately following the injection of GSH or Ginseng extract to the mouse intraperitoneally.
The protein content of the liver was measured at 30, 60 and 120 minutes, and a comparison was made with the normal.
The results obtained are summarized as follows;
1) The normal value of the protein content of the mouse liver was 106.2±2.4 mg/gm wet wt.
2) The protein content of the liver did not change appreciably from the normal by the injections of Ginseng extract or reduced glutathione.
3) When 1,200R of X-irradiation was administered, the protein content of the liver increased
moderately at 30 and 60 minutes, but the value returned to the normal at 120 minutes.
4) When GSH was injected prior to the X-irradiation, the liver protein increased slightly . at 30
minutes, but the value was generally within the normal limit.
5) Injection of Ginseng extract prior to the X-irradiation produced a slight increase of the protein content of the liver at 30 minutes but the value did not change greatly from the normal throughout the experiment.
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